- Title
- Late Afternoon Vigorous Exercise Increases Postmeal but Not Overnight Hypoglycemia in Adults with Type 1 Diabetes Managed with Automated Insulin Delivery
- Creator
- Morrison, Dale; Paldus, Barbora; Colman, Peter G.; Smart, Carmel E. M.; Seckold, Rowen; Grosman, Benyamin; Roy, Anirban; King, Bruce R.; Riddell, Michael C.; O'Neal, David Norman; Zaharieva, Dessi P.; Lee, Melissa H.; Vogrin, Sara; Jenkins, Alicia J.; Gerche, Andre La; MacIsaac, Richard J.; McAuley, Sybil A.; Ward, Glenn M.
- Relation
- Diabetes Technology & Therapeutics Vol. 24, Issue 12, p. 873-880
- Publisher Link
- http://dx.doi.org/10.1089/dia.2022.0279
- Publisher
- Mary Ann Liebert
- Resource Type
- journal article
- Date
- 2022
- Description
- Aim: To compare evening and overnight hypoglycemia risk after late afternoon exercise with a nonexercise control day in adults with type 1 diabetes using automated insulin delivery (AID). Methods: Thirty adults with type 1 diabetes using AID (Minimed 670G) performed in random order 40 min high intensity interval aerobic exercise (HIE), resistance (RE), and moderate intensity aerobic exercise (MIE) exercise each separated by >1 week. The closed-loop set-point was temporarily increased 2 h pre-exercise and a snack eaten if plasma glucose was ≤126 mg/dL pre-exercise. Exercise commenced at ∼16:00. A standardized meal was eaten at ∼20:40. Hypoglycemic events were defined as a continuous glucose monitor (CGM) reading <70 mg/dL for ≥15 min. Four-hour postevening meal and overnight (00:00-06:00) CGM metrics for exercise were compared with the prior nonexercise day. Results: There was no severe hypoglycemia. Between 00:00 and 06:00, the proportion of nights with hypoglycemia did not differ postexercise versus control for HIE (18% vs. 11%; P = 0.688), RE (4% vs. 14%; P = 0.375), and MIE (7% vs. 14%; P = 0.625). Time in range (TIR) (70-180 mg/dL), >75% for all nights, did not differ between exercise conditions and control. Hypoglycemia episodes postmeal after exercise versus control did not differ for HIE (22% vs. 7%; P = 0.219) and MIE (10% vs. 14%; P > 0.999), but were greater post-RE (39% vs. 10%; P = 0.012). Conclusions: Overnight TIR was excellent with AID without increased hypoglycemia postexercise between 00:00 and 06:00 compared with nonexercise days. In contrast, hypoglycemia risk was increased after the first meal post-RE, suggesting the importance of greater vigilance and specific guidelines for meal-time dosing, particularly with vigorous RE. ACTRN12618000905268.
- Subject
- type 1 diabetes; automated insulin delivery; exercise; glucose control; hypoglycemia; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1484403
- Identifier
- uon:51324
- Identifier
- ISSN:1520-9156
- Language
- eng
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